[1]马鹏,王建村,黄杰,等.胶质瘤组织TMEM168的表达与病人预后的关系[J].中国临床神经外科杂志,2022,27(07):570-573.[doi:10.13798/j.issn.1009-153X.2022.07.013]
　MA Peng,WANG Jian-cun,HUANG Jie,et al.Expression of TMEM168 in glioma tissues and its relationship with glioma patients' prognosis[J].,2022,27(07):570-573.[doi:10.13798/j.issn.1009-153X.2022.07.013]
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胶质瘤组织TMEM168的表达与病人预后的关系()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
27
期数:
2022年07期
页码:
570-573
栏目:
论著
出版日期:
2022-07-31

文章信息/Info

Title:
Expression of TMEM168 in glioma tissues and its relationship with glioma patients' prognosis
文章编号:
1009-153X(2022)07-0570-04
作者:
马鹏; 王建村; 黄杰; 薛强
201800 上海，中国人民解放军海军军医大学第三附属医院神经外科（马鹏、王建村、黄杰、薛强）
Author(s):
MA Peng;  WANG Jian-cun;  HUANG Jie;  XUE Qiang
Department of Neurosurgery, The Third Affiliated Hospital of Naval Military Medical University, PLA, Shanghai 201800, China
关键词:
胶质瘤; 跨膜蛋白168; TMEM168; 生存预后; 危险因素; 基因表达
Keywords:
Glioma;  Transmembrane protein 168;  Survival prognosis;  Risk factor;  Gene expression
分类号:
R739.41;Q786
DOI:
10.13798/j.issn.1009-153X.2022.07.013
文献标志码:
A
摘要:
目的 探讨跨膜蛋白（TMEM）168在胶质瘤组织中的表达及其与病人预后的关系。方法 选取2014年6月至2016年9月手术切除的符合标准的脑胶质瘤140例和颅脑损伤内减压术中切取的非肿瘤脑组织50例为对照，免疫组化染色检测TMEM168的表达。胶质瘤病人随访截止2021年10月，记录总生存期（OS）及无进展生存期（PFS）。结果 胶质瘤组织TMEM168高表达率[70.71%（99/140）]明显高于对照组[22.00%（11/50）；P<0.05]。高级别胶质瘤组织TMEM168高表达率[81.58%（62/76）]明显高于低级别胶质瘤组织[57.81%（37/64）；P<0.05]。140例胶质瘤术后随访3~60个月，死亡46例，复发87例。多因素Cox回归分析显示，TMEM168高表达是胶质瘤病人OS和PFS不良的独立危险因素（P<0.05）。生存曲线分析显示，TMEM168高表达胶质瘤病人中位OS、PFS较低表达病人明显缩短（P<0.05）。结论 胶质瘤组织TMEM168呈高表达，与胶质瘤病人不良生存预后有关。
Abstract:
Objective To investigate the expression of transmembrane protein (TMEM) 168 in glioma tissues and its relationship with glioma patients' prognosis. Methods The expressions of TMEM168 were detected using immunohistochemical staining in glioma tissues obtained from 140 glioma patients who underwent surgery from June 2014 to September 2016 and in non-tumor cerebral tissues obtained from 50 patients with traumatic brain injury who underwent decompression. Glioma patients were followed up until October 2021, and overall survival (OS) and progression-free survival (PFS) were recorded. Results The high expression rate of TMEM168 in glioma tissues [70.71% (99/140)]was significantly higher than that in the control group [22.00% (11/50); P<0.05]. The high expression rate of TMEM168 in high-grade glioma tissues [81.58% (62/76)]was significantly higher than that in low-grade glioma tissues [57.81% (37/64); P<0.05]. The followed up (range, 3~60 months) showed death in 46 patients and recurrence in 87 patients. Multivariate Cox regression analysis showed that high expression of TMEM168 was an independent risk factor for poor OS and PFS in glioma patients (P<0.05). Survival curve analysis showed that the median OS and PFS of glioma patients with high expression of TMEM168 were significantly shorter than those of glioma patients with low expression of TMEM168 (P<0.05). Conclusions The expression of TMEM168 in glioma tissues is up-regulated, which is related to the poor survival prognosis of glioma patients.

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备注/Memo

备注/Memo:
（2022-03-25收稿，2022-05-13修回）
通讯作者：王建村，E-mail：kfz3618@163.com
更新日期/Last Update: 2022-08-31