[1]云德波,罗波,杨学军.脑胶质瘤FBLIM1的表达及临床意义[J].中国临床神经外科杂志,2023,28(03):173-175178.[doi:10.13798/j.issn.1009-153X.2023.03.009]
　YUN De-bo,LUO Bo,YANG Xue-jun.Expression of FBLIM1 in human brain gliomas and its clinical significance based on bioinformatics analysis[J].,2023,28(03):173-175178.[doi:10.13798/j.issn.1009-153X.2023.03.009]
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脑胶质瘤FBLIM1的表达及临床意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
28
期数:
2023年03期
页码:
173-175178
栏目:
论著
出版日期:
2023-03-31

文章信息/Info

Title:
Expression of FBLIM1 in human brain gliomas and its clinical significance based on bioinformatics analysis
文章编号:
1009-153X（2023）03-0173-03
作者:
云德波; 罗波; 杨学军
637000四川，南充市中心医院神经外科（云德波、罗波）；100000北京，北京清华长庚医院神经外科（杨学军）
Author(s):
YUN De-bo1;  LUO Bo1;  YANG Xue-jun2
1.Department of Neurosurgery, Nanchong Central Hospital, Nanchong 637000, China; 2.Department of Neurosurgery, Tsinghua Changgung Hospital, Beijing 100000, China
关键词:
胶质瘤; FBLIM1; 基因表达; 生信分析
Keywords:
Glioma;  FBLIM1;  Gene expression;  Bioinformatics analysis
分类号:
A
DOI:
10.13798/j.issn.1009-153X.2023.03.009
文献标志码:
R739.41;Q786
摘要:
目的 探讨FBLIM1在脑胶质瘤中的表达及临床意义。方法 采用R软件分析UCSC数据库中癌症基因组图谱联合基因型组织表达数据集（TCGA、TARGET、GTEx）中的662例胶质瘤和1 157例正常脑组织的FBLIM1表达水平。利用TCGA数据库698例胶质瘤mRNA-seq及临床数据分析FBLIM1表达与胶质瘤临床特征的关系，用Cox比例回归风险模型分析胶质瘤生存预后的影响因素，采用Kaplan-Meier法分析TCGA数据库及中国脑胶质瘤基因组图谱（CGGA）数据库共计1 975例胶质瘤的FBLIM1表达与生存预后的关系。结果 胶质瘤FBLIM1表达水平较正常脑组织明显增高（P<0.05），且肿瘤WHO分级越高，FBLIM1表达水平越高（P<0.05）；胶质瘤FBLIM1表达与IDH基因状态、1p/19q联合缺失、WHO分级及病人年龄显著相关（P<0.05）；FBLIM1过表达为胶质瘤病人生存预后不良的独立危险因素（OR=1.444；95% CI 1.032~2.020；P<0.05）；生存曲线分析显示FBLIM1高表达的胶质瘤病人中位总生存期较低表达病人明显缩短（P<0.05）。结论 胶质瘤FBLIM1呈高表达，与病人生存预后不良相关。
Abstract:
Objective To investigate the expression of FBLIM1 in human brain gliomas and its and clinical significance. Methods The expression levels of FBLIM1 in 662 gliomas and 1 157 normal brain tissues were analyzed using R software, which were obtained from the Cancer Genome Atlas combined with genotype tissue expression data set (TCGA, TARGET, GTEx) in UCSC database. The relationship between the expression of FBLIM1 and the clinical characteristics of glioma patients was analyzed using glioma mRNA-seq and clinical data of 698 glioma patients obtianed from the TCGA database, and the risk factors for the survival prognosis of glioma patients were analyzed using Cox proportional regression risk model. Kaplan-Meier method was used to analyze the relationship between FBLIM1 expression and survival prognosis of 1 975 glioma patients in the TCGA database and the Chinese glioma Genome Atlas (CGGA) database. Results The expression level of FBLIM1 in glioma tissues was significantly higher than that in the normal cerebral tissues (P<0.05), and the expression level of FBLIM1 signifcantly increased as the tumor WHO grade increased (P<0.05). The expression of FBLIM1 in glioma tissues was significantly correlated with IDH, 1p/19q co-deletion, WHO grade and age of patients (P<0.05). Overexpression of FBLIM1 was an independent risk factor for poor survival prognosis in glioma patients (OR=1.444; 95% CI 1.032~2.020; P<0.05). Survival curve analysis showed that the median overall survival of glioma patients with high FBLIM1 expression was significantly shorter than that of patients with low FBLIM1 expression (P<0.05). Conclusions FBLIM1 is highly exxpressed in glioma tissues, which is associated with poor survival prognosis of glioma patients.

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备注/Memo

备注/Memo:
（2023-01-03收稿，2023-02-11修回）
通讯作者：杨学军，E-mail：ydenny@126.com
更新日期/Last Update: 2022-04-30