[1]徐敬轩　杨　岩　张　勖　郭　正　喀斯木　栾新平.环状RNA circ-0014359在胶质瘤组织中的表达及意义[J].中国临床神经外科杂志,2020,(10):680-682.[doi:10.13798/j.issn.1009-153X.2020.10.007]
　XU Jing-xuan,YANG Yan,ZHANG Xu,et al.Expression of circRNA circ-0014359 in human glioma tissues and its clinical significance[J].,2020,(10):680-682.[doi:10.13798/j.issn.1009-153X.2020.10.007]
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环状RNA circ-0014359在胶质瘤组织中的表达及意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2020年10期
页码:
680-682
栏目:
论著
出版日期:
2020-10-25

文章信息/Info

Title:
Expression of circRNA circ-0014359 in human glioma tissues and its clinical significance
文章编号:
1009-153X（2020）10-0680-03
作者:
徐敬轩　杨　岩　张　勖　郭　正　喀斯木　栾新平
830028 乌鲁木齐，新疆医科大学第二附属医院神经外科（徐敬轩、杨　岩、张　勖、郭　正、喀斯木、栾新平）
Author(s):
XU Jing-xuan;  YANG Yan;  ZHANG Xu;  GUO Zheng;  Kasmu;  LUAN Xin-ping.
Department of Neurosurgery, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China
关键词:
胶质瘤; 环状RNA; circ-0014359; 预后
Keywords:
Glioma;  Circular RNA circ-0014359;  Prognosis
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2020.10.007
文献标志码:
A
摘要:
目的 探讨环状RNA circ-0014359（简称circ-0014359）在胶质瘤组织中的表达及意义。方法 实时定量PCR法检测118例胶质瘤组织和60例正常脑组织circ-0014359的表达水平。以circ-0014359表达量中位数为截断值，分为高表达和低表达。随访结束时间为2019年6月，总生存期（OS）为术后第1天至死亡或最后一次随访，无进展生存期（PFS）为术后至第一次发生疾病进展或任何原因死亡的时间。结果 胶质瘤组织circ-0014359表达水平明显高于正常脑组织（P<0.05）。随胶质瘤病理级别增高，circ-0014359表达水平明显增高（P<0.05）。多因素Cox比例回归风险模型分析结果显示，circ-0014359高表达是胶质瘤病人OS和PFS较短的独立影响因素（P<0.05）。生存曲线分析显示，高表达组OS和PFS[分别为（25.31±8.03）个月和（15.22±3.13）个月]明显低于低表达组[分别为（35.19±7.03）个月和（19.32±2.84）个月；P<0.05]。结论 胶质瘤组织circ-0014359呈高表达，并且与不良预后有关。
Abstract:
Objective To investigate the expression of circRNA circ-0014359 in human glioma tissues and its clinical significance. Methods The expressions of circRNA circ-0014359 were detected in glioma tissues obtained from 118 patients with glioma and in normal brain tissues obtained from 60 patients with traumatic brain injury by real-time quantitative PCR. With the median expression lvele of circRNA circ-0014359 as the cutoff value, the glioma patients were divided into high expression group and low expression group. The end of follow-up time was June 2019. The overall survival (OS) was from the first day after surgery to death or the last follow-up. The progression-free survival (PFS) was from the first postoperative disease progression or death from any cause. Results The expression level of circRNA circ-0014359 in glioma tissues was significantly higher than that in normal brain tissues (P<0.05). The expression level of circRNA circ-0014359 in low-grade glioma tissues was significantly lower than that in high-graode glioma tissues (P<0.05). The analysis of multivariate Cox proportional regression risk model showed that the high expression of circRNA circ-0014359 was an independent risk factor of shorter OS and PFS in glioma patients (P<0.05). Survival curve analysis showed that OS and PFS in the high expression group [(25.31±8.03) months and (15.22±3.13) months, respectively] were significantly shorter than those in the low expression group [(35.19±7.03) months and (19.32±2.84) months, respectively; P<0.05]. Conclusion CircRNA circ-0014359 is highly expressed in glioma tissue and is related to poor prognosis of patients with glioma.

参考文献/References:

[1] Gusyatiner O, Hegi ME. Glioma epigenetics: from subclassi-fication to novel treatment options [J]. Semin Cancer Biol, 2018, 51: 50-58.
[2] Belousova EA, Filipenko ML, Kushlinskii NE. Circular RNA: new regulatory molecules [J]. Bull Exp Biol Med, 2018, 164(6): 803-815.
[3] Shi F, Shi Z, Zhao Y, et al. CircRNA hsa-circ-0014359 promotes glioma progression by regulating miR-153/PI3K signaling [J]. Biochem Biophys Res Commun, 2019, 510(4): 614-620.
[4] Zhang HD, Jiang LH, Sun DW, et al. CircRNA: a novel typeof biomarker for cancer [J]. Breast Cancer, 2018, 25(1): 1-7.
[5] 戚前生，赵　红，刘建雄. 环状RNA在神经胶质瘤中的研究进展[J]. 中国肿瘤外科杂志，2019，11（1）：66-70.
[6] Verduci L, Strano S, Yarden Y, et al. The circRNA-microRNA code: emerging implications for cancer diagnosis and treatment [J]. Mol Oncol, 2019, 13(4): 669-680.
[7] Jin P, Huang Y, Zhu P, et al. CircRNA circHIPK3 serves as a prognostic marker to promote glioma progression by regu-lating miR-654/IGF2BP3 signaling [J]. Biochem Biophys Res Commun, 2018, 503(3): 1570-1574.
[8] Bian L, Zhi X, Ma L, et al. Hsa_circRNA_103809 regulated the cell proliferation and migration in colorectal cancer via miR-532-3p / FOXO4 axis [J]. Biochem Biophys Res Commun, 2018, 505(2): 346-352.
[9] Huang XY, Huang ZL, Zhang PB, et al. CircRNA-100338 is associated with mtor signaling pathway and poor progno-sis in hepatocellular carcinoma [J]. Front Oncol, 2019, 9: 392-340.
[10] Lipp ES, McLendon RE. Tissue is the issue: biomarkers of prognosis and classification in adult gliomas [J]. Sem Oncol Nurs, 2018, 34(5): 430-442.

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备注/Memo

备注/Memo:
2020-04-26收稿，2020-06-28修回
基金项目：新疆维吾尔自治区自然科学基金（2019D01C235）
通讯作者：栾新平，E-mail：Luanxinping4324177@163.com
更新日期/Last Update: 2020-10-20