[1]夏小超,王子豪,熊平,等.Notch信号通路在胶质瘤中作用的研究进展[J].中国临床神经外科杂志,2024,29(11):686-689.[doi:10.13798/j.issn.1009-153X.2024.11.011]
　XIA Xiao-chao,WANG Zi-hao,XIONG Ping,et al.Research advances on the function of Notch signaling pathway in glioma[J].,2024,29(11):686-689.[doi:10.13798/j.issn.1009-153X.2024.11.011]
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Notch信号通路在胶质瘤中作用的研究进展()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
29
期数:
2024年11期
页码:
686-689
栏目:
综述
出版日期:
2024-11-30

文章信息/Info

Title:
Research advances on the function of Notch signaling pathway in glioma
文章编号:
1009-153X（2024）11-0686-04
作者:
夏小超; 王子豪; 熊平; 宋旅萌; 程银川; 李舜
637000四川南充，川北医学院附属医院神经外科（夏小超、王子豪、熊平、宋旅萌、程银川、李舜）
Author(s):
XIA Xiao-chao;  WANG Zi-hao;  XIONG Ping;  SONG Lü-meng;  CHENG Yin-chuan;  LI Shun
Department of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
关键词:
胶质瘤; Notch信号通路; 肿瘤微环境; 肿瘤干细胞
Keywords:
Notch signaling pathway;  glioma;  Tumor Microenvironment;  Tumor stem cells
分类号:
R 739.41
DOI:
10.13798/j.issn.1009-153X.2024.11.011
文献标志码:
A
摘要:
Notch信号通路是一条重要的细胞信号传导途径。Notch受体经历三次切割后转位到细胞核，调节靶基因的转录，参与多种组织器官的发育和稳态。Notch信号通路异常与肿瘤发生、发展密切相关。研究表明，Notch信号通路在胶质瘤中的异常激活促进肿瘤细胞增殖、侵袭，影响肿瘤微环境和维持干细胞稳态。因此，有学者认为Notch信号通路可能是胶质瘤一种潜在的治疗靶点。有研究报道抑制Notch信号通路治疗胶质瘤，但这些药物的疗效有待商榷。近年来，随着Notch信号通路在胶质瘤中研究的不断深入，其有望为胶质瘤的治疗提供新的思路。本文就Notch信号通路在胶质瘤中的作用机制及其研究进展进行综述。
Abstract:
The Notch signaling pathway, functioning as a critical intercellular signaling conduit, exerts a vital role in the development and homeostasis maintenance of diverse tissues and organs. Once the Notch receptor undergoes three proteolytic cleavages, its intracellular domain (NICD) translocates to the nucleus and governs the transcriptional expression of a series of target genes. Researches conducted in recent years have indicated that the aberrant activation of the Notch signaling pathway is closely associated with the genesis and progression of tumors, particularly in glioma. The excessive activation of the Notch signaling pathway not only promotes the proliferation and invasion of tumor cells but also influences the tumor microenvironment and maintains the homeostasis of glioma stem cells. Consequently, the Notch signaling pathway is regarded as one of the potential therapeutic targets for glioma. Despite the fact that there have been studies reporting the treatment of glioma by inhibiting the Notch signaling pathway, the clinical efficacy of existing drugs still requires further validation. With the in-depth investigation of the mechanism of the Notch signaling pathway in glioma, this pathway is anticipated to offer novel strategies and notions for the treatment of glioma. This article will review the mechanism of the Notch signaling pathway in glioma and its latest research advancements.

参考文献/References:

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备注/Memo

备注/Memo:
（2023-03-20收稿，2023-11-06修回）
通信作者：李　舜，Email：morelee@163.com
更新日期/Last Update: 2024-11-30