[1]王娇燕　温　群　张欢欢　崔贝贝　林丽萍.常规MRI纹理分析鉴别WHO Ⅱ级与Ⅲ级胶质瘤的价值[J].中国临床神经外科杂志,2018,(12):785-787.[doi:10.13798/j.issn.1009-153X.2018.12.006]
　WANG Jiao-yan,WEN Qun,ZHANG Huan-huan,et al.Value of texture analysis of conventional MRI to differential diagnoses of WHO grade Ⅱ from Ⅲ gliomas[J].,2018,(12):785-787.[doi:10.13798/j.issn.1009-153X.2018.12.006]
点击复制

常规MRI纹理分析鉴别WHO Ⅱ级与Ⅲ级胶质瘤的 价值()
分享到：

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2018年12期
页码:
785-787
栏目:
论著
出版日期:
2018-12-25

文章信息/Info

Title:
Value of texture analysis of conventional MRI to differential diagnoses of WHO grade Ⅱ from Ⅲ gliomas
文章编号:
1009-153X（2018）12-0785-03
作者:
王娇燕　温　群　张欢欢　崔贝贝　林丽萍
200021 上海，上海中医药大学附属曙光医院放射科（王娇燕、温　群）；200240 上海，复旦大学附属上海市第五人民医院放射科（张欢 欢、崔贝贝、林丽萍）
Author(s):
WANG Jiao-yan1;  WEN Qun1;  ZHANG Huan-huan2;  CUI Bei-bei2;  LIN Li-ping2.
1. Department of Diagnostic Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China; 2. Department of Diagnostic Radiology, The Fifth People’s Hospital, Fudan University, Shanghai 200240, China
关键词:
胶质瘤; 磁共振成像; 纹理分析; 肿瘤分级; 鉴别诊断
Keywords:
Gliomas;  MRI;  Texture analysis;  Neoplasm grading
分类号:
R739.41;R445.2
DOI:
10.13798/j.issn.1009-153X.2018.12.006
文献标志码:
A
摘要:
目的 探讨常规MRI纹理分析在WHO Ⅱ级与Ⅲ级胶质瘤鉴别中的临床价值。方法 回顾性分析经病理证实的40例WHO Ⅱ级和46例WHO Ⅲ级胶 质瘤的常规MRI影像。在MaZda上勾画肿瘤最大层面进行纹理分析，选出与肿瘤级别显著相关的特征纹理参数并统计分析各特征纹理参数的诊断效能。 结果 四种MRI序列（包括T1WI、T2WI、FLAIR、T1WI增强）鉴别WHO Ⅱ级和Ⅲ级胶质瘤的最小误判率为9.30%，出现在T2WI序列中。多元Logistic回归 分析显示，T2WI序列中熵（OR=2.497；P=0.009 ）及游程长非均匀度因子（OR=1.844；P=0.011）与胶质瘤级别独立相关。根据ROC曲线分析结果，以 熵=2.46为阈值鉴别WHO Ⅱ级和Ⅲ级胶质瘤的曲线下面积为0.843，敏感性、特异性分别为0.814、0.767；以游程长非均匀度因子=363.22为阈值鉴别 WHO Ⅱ级和Ⅲ级胶质瘤的曲线下面积为0.808，敏感性、特异性分别为0.794、0.778。结论 常规MRI纹理分析有助于鉴别WHO Ⅱ级与Ⅲ级胶质瘤， T2WI纹理参数中熵及游程长非均匀度因子的鉴别诊断价值最高。
Abstract:
Objective To investigate the diagnostic value of texture analysis of conventional MRI to differentiating grade Ⅱ glioma from Ⅲ glioma. Methods Forty patients with WHO grade Ⅱ glioma and 46 patients with WHO grade Ⅲ glioma confirmed pathologically after the surgery received conventional MRI before the surgery. Texture feature of the lesions were extracted with MaZda image analysis soft-ware. Then characteristic texture parameters significantly related to tumor grade were selected and the diagnostic efficiency of each feature texture parameter was evaluated by statistical analysis. Results The entropy and run length non-uniformity of T2WI were significantly correlated with the tumorous grade. The values of entropy and run length non-uniformity of grade Ⅲ glioma were significantly higher than those of grade Ⅱ glioma (P<0.05). When the optimal cutoff value of entropy and run length non-uniformity was 2.46 and 363.22 respectively, the value of area under receiver operating characteristic curve was the highest. Conclusions The texture analysis of conventional MRI may be helpful to differentiating grade Ⅱ glioma from Ⅲ glioma, The values of entropy and run length non-uniformity of T2WI to differentiation diagnosis of WHO grade Ⅱ glioma from Ⅲ glioma are significantly higher than any other texture parameters.

参考文献/References:

[1] 赛　克，陈忠平. 胶质瘤的疗效评价[J]. 中国临床神经外科杂志, 2016, 21（6）：321-322.
[2] Skogen K, Schulz A, Dormagen JB, et al. Diagnostic perfor-mance of texture analysis on MRI in grading cerebral gliomas [J]. Eur J Radiol, 2016, 85(4): 824-829.
[3] Kinoshita M, Sakai M, Arita H, et al. Introduction of high throughput magnetic resonance T2-weighted image texture analysis for WHO grade 2 and 3 gliomas [J]. PloS One, 2016, 11(10): e0164268.
[4] Ganeshan B, Skogen K, Pressney I, et al. Tumour heteroge-neity in oesophageal cancer assessed by CT texture analysis:Pre.liminary evidence of an association with tumour meta-bolism, stage, and survival [J]. Clin Radiol, 2012, 67(2): 157-164.
[5] 孙振国，汪秀玲，朱　辉，等. 纹理分析在原发性脑淋巴瘤与高级别胶质瘤鉴别诊断中的应用价值[J]. 临床放射学杂志，2017，36（9）：1229-1234.
[6] Kunimatsu A, Kunimatsu N, Kamiya K, et al. Comparison between glioblastoma and primary central nervous system lymphoma using MR image-based texture analysis [J]. MagnReson Med Sci, 2018, 17(1): 50-57.
[7] Tian Q, Yan LF, Zhang X, et al. Radiomics strategy for glio-ma grading using texture features from multiparametric MRI[J]. J Magn Reson Imaging, 2018. Epub ahead of print.

相似文献/References:

[1]常英男　王　策　赵天书.SOX2基因在胶质瘤中的表达及生物学作用[J].中国临床神经外科杂志,2016,(05):270.[doi:10.13798/j.issn.1009-153X.2016.05.005]
　CHANG Ying-nan,WANG Ce,ZHAO Tian-shu..Expression of SOX2 gene and its biological role in human gliomas[J].,2016,(12):270.[doi:10.13798/j.issn.1009-153X.2016.05.005]
[2]赛　克　陈忠平.胶质瘤的疗效评价[J].中国临床神经外科杂志,2016,(06):321.[doi:10.13798/j.issn.1009-153X.2016.06.001]
[3]许　耿　路俊锋　杨　忠　施建斌　吴秋月　王　烨　庄冬晓　吴劲松.神经电生理监测技术在功能区胶质瘤术中的应用[J].中国临床神经外科杂志,2016,(06):323.[doi:10.13798/j.issn.1009-153X.2016.06.002]
　XU Geng,LU Jun-feng,YANG Zhong,et al.Application of intraoperative neuroelectrophysiologic monitoring to gliomas resection in eloquent function brain regions[J].,2016,(12):323.[doi:10.13798/j.issn.1009-153X.2016.06.002]
[4]李剑峰　陈银生　赛　克　张湘衡　柯　超　杨群英　牟永告　许海雄　陈忠平.173例胶质瘤预后的影响因素分析[J].中国临床神经外科杂志,2016,(06):327.[doi:10.13798/j.issn.1009-153X.2016.06.003]
　LI Jian-feng,CHEN Yin-sheng,SAI Ke,et al.Prognostic factors for gliomas: analysis of 173 cases[J].,2016,(12):327.[doi:10.13798/j.issn.1009-153X.2016.06.003]
[5]云德波　杨宇焦　张　逵　范润金　张　渊　杜贻庆.瘤周谷氨酸、天门冬氨酸水平与胶质瘤继发性 癫痫的相关性[J].中国临床神经外科杂志,2016,(06):331.[doi:10.13798/j.issn.1009-153X.2016.06.004]
　YUN De-bo,YANG Yu-Jiao,ZHANG Kui,et al.Relationship of levels of glutamate and aspartate in peritumorous tissues with seizures in patients with gliomas[J].,2016,(12):331.[doi:10.13798/j.issn.1009-153X.2016.06.004]
[6]黄书岚　成于思　王　辉　汪超甲.FAK siRNA重组质粒的构建及其对胶质瘤U251细胞 增殖及侵袭能力的抑制作用[J].中国临床神经外科杂志,2016,(06):336.[doi:10.13798/j.issn.1009-153X.2016.06.006]
　HUANG Shu-lan,CHENG Yu-si,WANG Hui,et al.Construction of siRNA recombinant plasmid targeting focal adhesion kinase gene and its effect on the proliferation and invasiveness of human glioma U251cells[J].,2016,(12):336.[doi:10.13798/j.issn.1009-153X.2016.06.006]
[7]林　雨　张　恺　李　帅　杨学军.磁共振数字化手术单元在指导胶质瘤治疗中的作用[J].中国临床神经外科杂志,2016,(06):345.[doi:10.13798/j.issn.1009-153X.2016.06.009]
[8]戴黎明　徐成仕　王泽芬　曹长军　李志强.VEGF单抗对低氧环境下C6胶质瘤细胞侵袭性的影响[J].中国临床神经外科杂志,2016,(04):219.[doi:10.13798/j.issn.1009-153X.2016.04.009]
　DAI Li-ming,XU Cheng-shi,WANG Ze-fen,et al.Effect of nonoclonal antibody of VEGF on C6 glioma cells invasiveness under hypoxia and the role of FAK/Pyk2[J].,2016,(12):219.[doi:10.13798/j.issn.1009-153X.2016.04.009]
[9]彭泽生　田道锋　张申起　陈谦学.miR-370-3p对胶质母细胞瘤U87-MG细胞株增殖能力的影响[J].中国临床神经外科杂志,2016,(04):223.[doi:10.13798/j.issn.1009-153X.2016.04.010]
　PENG Ze-sheng,TIAN Dao-feng,ZHANG Shen-qi,et al.Effects of MircoRNA-370-3p on proliferation of glioma cell line U87-MG and its potential mechanism[J].,2016,(12):223.[doi:10.13798/j.issn.1009-153X.2016.04.010]
[10]冯　驰　郭双毅　程龙海　罗　杰.氯喹通过抑制自噬促进TRAIL诱导的胶质瘤细胞凋亡[J].中国临床神经外科杂志,2016,(04):227.[doi:10.13798/j.issn.1009-153X.2016.04.011]
　FENG Chi,GUO Shuang-yi,CHENG Long-hai,et al.Chloroquine promotes TRAIL-induced apoptosis of glioma cells through inhibition of autophagy[J].,2016,(12):227.[doi:10.13798/j.issn.1009-153X.2016.04.011]

备注/Memo

备注/Memo:
doi:10.13798/j.issn.1009-153X.2018.12.006 基金项目：上海市闵行区自然科学基金（2017MHZ42） 作者单位：200021 上海，上海中医药大学附属曙光医院放射科（王娇燕、温　群）；200240 上海，复旦大学附属上海市第五人民医院放射科（张欢 欢、崔贝贝、林丽萍） 通讯作者：林丽萍，E-mail：linlplucky@163.com
更新日期/Last Update: 2018-12-26