参考文献/References:
[1] Sthornsumetee S, Rich JN. New treatment strategies for malignant gliomas [J]. Expert Rev Anticancer Ther, 2006, 6(7): 1087-1104.
[2] Sthornsumetee S, Reardon DA, Desjardins A, et al. Molecu-larly targeted therapy for malignant glioma [J]. Cancer, 2007, 110(1): 13-24.
[3] Blume-Jensen P, Hunter T. Oncogenic kinase signalling [J]. Nature, 2001, 411(6835): 355-365.
[4] 唐剑英. 表皮生长因子受体家族信号转导与肿瘤治疗[J]. 国外医学·肿瘤学分册，2002，29（2）：95-97.
[5] 胡 兵，魏于全. 表皮生长因子受体靶向肿瘤生物治疗 [J]. 癌症，2004，23（4）：471-475.
[6] Lammering G, Valerie K, Lin PS, et al. Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor [J]. Clin Cancer Res, 2001,7(3): 682-690.
[7] Nilsson J, Vallbo C, Guo D, et al. Cloning, characterization, and expression of human LIG1 [J]. Biochem Biophys Res Commun, 2001, 284(5):1155-1161.
[8] Lindquist D, Nasman A, Tarjan M, et al. Expression of LRIG1 is associated with good prognosis and human papi-llomavirus status in oropharyngeal cancer [J]. Br J Cancer, 2014, 110(7): 1793-1800.
[9] Musacchio M, Perrimon N. The Drosophila kekkon genes:novel members of both the leucine-rich repeat and immu-noglobulin superfamilies expressed in the CNS [J]. Dev Bio, 1996, 178(1): 63-76.
[10] Ghiglione C, Carraway KL 3rd , Amundadottir LT, et al. The trasmembrane molecule kekkon-1 acts in a feedback loop to negatively regulate the activity of the drosophila EGF receptor during ongensis [J]. Cell, 1999, 96(6): 847-856.
[11] Guo D, Holmund C, Henriksson R, et al. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea [J]. Genomics, 2004, 84(1): 157-165.
[12] Guo D, Nilsson J, Haapasalo H, et al. Perinuclear leucine-rich repeats and Immunoglobulin- like domain protein(LRIG1-3) as prognostic indicators in Astrocytic tumors [J]. Acta Neuropathol (Ber1), 2006, 111: 238-246.
[13] Thomasson M, Hedman H, Guo D, et al. LRIG1 and epider-mal growth factor receptor in renal cell carcinoma: a quan-titative RT-PCR and immunohistochemical analysis [J]. Br J Cancer, 2003, 89(7): 1285-1289.
[14] 叶 飞，郭东升，易 伟，等. 过度表达LRIG1基因逆转人胶质瘤侵袭性的机制[J]. 中华实验外科杂志，2005，22（2）：200-202.
[15] 易 伟，叶 飞，郭东升，等. LRIG1基因在人星形细胞瘤中的表达与意义[J]. 中国临床神经外科杂志，2006，11（1）：29-31.
[16] Ye F, Gao Q, Xu T, et al. Upregulation of LRIG1 supresses malignant glioma cell growth by attenuating EGFR activity [J]. J Neurooncol, 2009, 94(2): 183-194.
[17] Sibilia M, Kroismayr R, Lichtenberger BM, et al. The epi-dermal growth factor receptor: from development to tumori-genesis [J]. Differentiation, 2007, 75(9): 770-100.
[18] Yi W, Ye F, Duo D, et al. Expression and significance of LRIG1 gene in human astrocytomas [J]. Chinese-Greman J Clinc Oncol, 2005, 4(4): 225-228.
[19] Huang PH, Xu AM, White FM. Oncogenic EGFR signaling networks in glioma [J]. Sci Signal, 2009, 2(87): re6.
[20] Mao F, Wang B, Xiao Q, et al. A role for Lrig1 in the regula-tion of malignant glioma aggressiceness [J]. Int J Oncol, 2013, 42: 1081-1087.
[21] Liu BH, Chen QX, Tian DF, et al. Increased leucine-tich repeats and immunoglobulin-like domains 1 expression enhances chenmosensitivity in glioma [J]. Neural Regener Res, 2011, 6(32): 2516-2520.
[22] 丁建军，郭振涛，刘宝辉，等. 多亮氨酸重复区免疫球蛋白样蛋白1与胶质瘤细胞株化疗敏感性之间的关系[J]. 中华实验外科杂志，2012，29（7）：1342-1344.
[23] Lal B, Xiao S, Abounader R, et al. Targeting the c-Met pathway potentiates glioblastoma responses to γ-radioation [J]. Clin Cancer Res, 2005, 11(12): 4479-4486.
[24] Goldoni S, Iozzo RA, Kay P, et al. A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity [J]. Oncogene, 2007, 26: 368-381.
[25] Yi W, Holmlund C, Nilsson J, et al. Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1 [J]. Exp Cell Res, 2010, 317(4): 504-512.
[26] Maga G, Hubscher U. proliferation cell nuclear antigen (PCNA): a dancer with many parters [J]. J Cel Sci, 2003, 116(Pt 15): 3051-3060.
[27] Johansson M, Oudin A, Tiemann K, et al. The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo gli-oma growth irrespective of EGF receptor status [J]. Neuro Oncol, 2013, 15(9): 1200-1211.
相似文献/References:
[1]常英男 王 策 赵天书.SOX2基因在胶质瘤中的表达及生物学作用[J].中国临床神经外科杂志,2016,(05):270.[doi:10.13798/j.issn.1009-153X.2016.05.005]
CHANG Ying-nan,WANG Ce,ZHAO Tian-shu..Expression of SOX2 gene and its biological role in human gliomas[J].,2016,(12):270.[doi:10.13798/j.issn.1009-153X.2016.05.005]
[2]赛 克 陈忠平.胶质瘤的疗效评价[J].中国临床神经外科杂志,2016,(06):321.[doi:10.13798/j.issn.1009-153X.2016.06.001]
[3]许 耿 路俊锋 杨 忠 施建斌 吴秋月 王 烨 庄冬晓 吴劲松.神经电生理监测技术在功能区胶质瘤术中的应用[J].中国临床神经外科杂志,2016,(06):323.[doi:10.13798/j.issn.1009-153X.2016.06.002]
XU Geng,LU Jun-feng,YANG Zhong,et al.Application of intraoperative neuroelectrophysiologic monitoring to gliomas resection in eloquent function brain regions[J].,2016,(12):323.[doi:10.13798/j.issn.1009-153X.2016.06.002]
[4]李剑峰 陈银生 赛 克 张湘衡 柯 超 杨群英 牟永告 许海雄 陈忠平.173例胶质瘤预后的影响因素分析[J].中国临床神经外科杂志,2016,(06):327.[doi:10.13798/j.issn.1009-153X.2016.06.003]
LI Jian-feng,CHEN Yin-sheng,SAI Ke,et al.Prognostic factors for gliomas: analysis of 173 cases[J].,2016,(12):327.[doi:10.13798/j.issn.1009-153X.2016.06.003]
[5]云德波 杨宇焦 张 逵 范润金 张 渊 杜贻庆.瘤周谷氨酸、天门冬氨酸水平与胶质瘤继发性
癫痫的相关性[J].中国临床神经外科杂志,2016,(06):331.[doi:10.13798/j.issn.1009-153X.2016.06.004]
YUN De-bo,YANG Yu-Jiao,ZHANG Kui,et al.Relationship of levels of glutamate and aspartate in peritumorous tissues with seizures in patients with gliomas[J].,2016,(12):331.[doi:10.13798/j.issn.1009-153X.2016.06.004]
[6]黄书岚 成于思 王 辉 汪超甲.FAK siRNA重组质粒的构建及其对胶质瘤U251细胞
增殖及侵袭能力的抑制作用[J].中国临床神经外科杂志,2016,(06):336.[doi:10.13798/j.issn.1009-153X.2016.06.006]
HUANG Shu-lan,CHENG Yu-si,WANG Hui,et al.Construction of siRNA recombinant plasmid targeting focal adhesion kinase gene and its effect on the proliferation and invasiveness of human glioma U251cells[J].,2016,(12):336.[doi:10.13798/j.issn.1009-153X.2016.06.006]
[7]林 雨 张 恺 李 帅 杨学军.磁共振数字化手术单元在指导胶质瘤治疗中的作用[J].中国临床神经外科杂志,2016,(06):345.[doi:10.13798/j.issn.1009-153X.2016.06.009]
[8]戴黎明 徐成仕 王泽芬 曹长军 李志强.VEGF单抗对低氧环境下C6胶质瘤细胞侵袭性的影响[J].中国临床神经外科杂志,2016,(04):219.[doi:10.13798/j.issn.1009-153X.2016.04.009]
DAI Li-ming,XU Cheng-shi,WANG Ze-fen,et al.Effect of nonoclonal antibody of VEGF on C6 glioma cells invasiveness under hypoxia and the role of FAK/Pyk2[J].,2016,(12):219.[doi:10.13798/j.issn.1009-153X.2016.04.009]
[9]彭泽生 田道锋 张申起 陈谦学.miR-370-3p对胶质母细胞瘤U87-MG细胞株增殖能力的影响[J].中国临床神经外科杂志,2016,(04):223.[doi:10.13798/j.issn.1009-153X.2016.04.010]
PENG Ze-sheng,TIAN Dao-feng,ZHANG Shen-qi,et al.Effects of MircoRNA-370-3p on proliferation of glioma cell line U87-MG and its potential mechanism[J].,2016,(12):223.[doi:10.13798/j.issn.1009-153X.2016.04.010]
[10]冯 驰 郭双毅 程龙海 罗 杰.氯喹通过抑制自噬促进TRAIL诱导的胶质瘤细胞凋亡[J].中国临床神经外科杂志,2016,(04):227.[doi:10.13798/j.issn.1009-153X.2016.04.011]
FENG Chi,GUO Shuang-yi,CHENG Long-hai,et al.Chloroquine promotes TRAIL-induced apoptosis of glioma cells through inhibition of autophagy[J].,2016,(12):227.[doi:10.13798/j.issn.1009-153X.2016.04.011]